The nuclear receptor PPARc individually responds to serotonin- and fatty acid-metabolites
نویسندگان
چکیده
Tsuyoshi Waku, Takuma Shiraki, Takuji Oyama, Kanako Maebara, Rinna Nakamori and Kosuke Morikawa* The Takara Bio Endowed Division, Department of Biomolecular Recognition, Institute for Protein Research, Osaka University, Open Laboratories of Advanced Bioscience and Biotechnology, Furuedai, Suita, Osaka, Japan and Department of Biochemistry, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan
منابع مشابه
The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites.
The nuclear receptor, peroxisome proliferator-activated receptor γ (PPARγ), recognizes various synthetic and endogenous ligands by the ligand-binding domain. Fatty-acid metabolites reportedly activate PPARγ through conformational changes of the Ω loop. Here, we report that serotonin metabolites act as endogenous agonists for PPARγ to regulate macrophage function and adipogenesis by directly bin...
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تاریخ انتشار 2010